DEVELOPMENT OF ORAL CONTROLLED RELEASE TABLET WITH SOLUBILITY ENHANCEMENT OF REPAGLINIDE

Mathew George*1, Lincy Joseph2, Vandana Gupta3, V.Jyothilakshmi Nair4
Page No. 11-23

The present study was carried out to develop oral controlled release tablets of Repaglinide with a
rationale of providing improved solubility and better patient compliance, will serve to provide
effective mode of treatment to elderly, impaired and non-cooperative patient suffering from
diabetes. The Repaglinide-ß-cyclodextrin complex was prepared in order to increase the solubility
of drug. The inclusion efficiency of different ratios of Repaglinide-ß-cyclodextrin complex was
calculated, that shows the inclusion efficiency of 1:2 molar ratio complex is highest. The oral
tablets of Repaglinide (F1 to F4) were prepared by direct compression method using super
disintegrants, for optimization of the diluents. The value of pre-compression of blends and postcompression
tablets exhibited satisfactorily results. The formulation F4 complied with all the
physical parameters such as hardness, friability and disintegration time, and taken for further
studies. Solubility studies revealed that complexing agents contribute to solubility enhancement of
the drug.
Keywords:Repaglinide,Beta-cyclodextrin,Simulated gastric fluid,Friability,Drug dispersion