Antibacterial activity of the venom protein from Periphylla periphylla against human pathogens

T. Aravindhan *, S. Saravanan, S. Mahendran and P. Seedevi
Page No. 1-5

The aim of this work was to the venom protein extract from P. Periphylla and characterized the
molecular weight of 48 and 26 kDa protein respectively. Further the venom protein was evaluated
for the antibacterial activity against 10 human clinical pathogens like Staphylococcus aureus,
Klebsiella pneumoniae, Salmonella typhi, Vibrio cholerae, Klebsiella oxytoca, Escherichia coli,
Salmonella paratyphi, Proteus mirabilis, Vibrio parahaemolyticus and Streptococcus pyogenes.
From this research the venom protein found to have the antibacterial activity against 7 bacterial
strains, of the 10 pathogens tested. The venom protein showed the highest levels of antibacterial
activity with 100 μg/ml. Based on the result present investigation suggested that venom protein
from P. periphylla can be used to protect human bacterial diseases.
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Keywords: P. periphylla, venom protein, SDS-PAGE, Antibacterial activity.